About the Research Laboratory of Michele Redell, M.D., Ph.D.
Dr. Michele Redell is conducting research under the mentorship of Dr. David Tweardy, Chief of the Section of Infectious Diseases at Baylor College of Medicine. She is interested in understanding the molecular steps that determine whether an immature cell in the bone marrow becomes a normal mature neutrophil or a malignant leukemia cell.
She is focusing on a signaling protein known as Stat3, which has two main variants and is activated in response to cytokines that control myeloid cell survival, proliferation, and maturation. She is investigating the distinct roles of the Stat3 variants in normal neutrophil development in mice. Stat3 is also known to be an important protein in many kinds of cancer, including acute myeloid leukemia (AML). Dr. Redell is studying the mechanisms by which Stat3 becomes inappropriately activated in AML. With Dr. Tweardy, she is working with new agents that can block Stat3, to test their potential effectiveness as novel therapies for cancers including AML.
Dr. Michele Redell’s lab is part of the Leukemia Research Labs.
Wei Liu, Ph.D.