About the Research Laboratory of Lisa Wang, MD
In coordination with Dr. Sharon Plon, Dr. Lisa Wang has assembled the largest world-wide registry of patients with Rothmund-Thomson syndrome (RTS). Registrants participate in IRB-approved research protocols at Baylor College of Medicine (BCM). Associated with the Cancer Genetics and Genomics Program, the aim of the RTS research protocols is:
- to increase our understanding of the molecular basis of RTS and related disorders, and
- to further understand the mechanisms that predispose individuals to genomic instability and osteosarcoma development
The main goal of Dr. Lisa Wang’s translational laboratory research work is to understand genetic factors which predispose patients to osteosarcoma (OS), the most common malignant bone tumor in children and adolescents.
Dr. Wang and her colleagues focus on the gene product of RECQL4. RECQL4 belongs to a family of RECQ helicases that are important for maintaining genomic stability and for tumor suppression. It is found to be mutated in two-thirds of RTS patients. RTS patients with RECQL4 mutations have a significantly increased risk of developing osteosarcoma and other bone abnormalities.
Her lab is now characterizing the bone turnover status of RTS patients and examining the molecular and cellular consequences of loss of RECQL4 on the skeletal system using mouse models of RTS. They are also exploring the mechanistic role of RTS in bone development and osteosarcoma through its participation in cellular signaling pathways.
Linchao Lu, M.S., Ph.D. is a Postdoctoral Associate who received his graduate degree training in the Department of Cell Biology at Albert Einstein College of Medicine where he studied the role of O-fucose glycans in Notch signaling. His current work focuses on the development and characterization of genetically engineered mouse models of Rothmund-Thomson syndrome in order to study the role of RECQL4 in skeletal development and osteosarcoma predisposition.
Laboratory Manager and Research Associate
Weidong Jin, M.S. received his Master of Science degree from Peking Union Medical College in Beijing China, where he studied the role of bcr-abl gene in chronic myeloid leukemia. He previously did research at the Chinese Academy of Medical Sciences in the field of experimental hematology and at M.D. Anderson Cancer Center in the field of experimental therapeutics before coming to Baylor in 2004. Weidong Jin is currently investigating the cellular phenotype of RECQL4-deficient cells and the mechanistic role of RECQL4 in bone development and osteosarcoma.
Clinical Research Coordinator
Ta-Tara Rideau is the Clinical Research Coordinator for the Rothmund-Thomson syndrome (RTS) research studies. She is responsible for enrolling subjects into IRB-approved protocols, carrying out testing procedures related to research protocol guidelines, maintaining research study databases and approvals, and maintaining research subject correspondences. She has been instrumental in the development of the RTS Patient Support Group and RTS Foundation.
Bangyi Mao is a Research Assistant for the Rothmund-Thomson syndrome studies. She previously did research in the field of Allergy and Immunology at Baylor before join our team in 2014. She is currently studying the phenotype of Recql4-deficient mice and the effects of Recql4-deficiency in skeletal development and osteosarcoma predisposition.