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Date:August 10, 2012

Pulivarthi Rao, Ph.D.

Pulivarthi Rao, Ph.D.Associate Director
Cancer Cytogenetics Core Laboratory
Texas Children’s Cancer Center

Associate Professor
Department of Pediatrics
Section of Hematology-Oncology
Baylor College of Medicine

Pulivarthi Rao, Ph.D.
1102 Bates Street, Suite 1570
Houston, TX 77030

Phone: 832-824-4820
Fax: 832-825-4038
Email: prao@bcm.edu

Biography

The main goal of Dr. Pulivarthi Rao’s laboratory is the analysis of the genetic basis of deregulation of cellular proliferation and differentiation associated with malignant transformation. The laboratory staff investigates several tumor types, most notably osteosarcoma and multiple myeloma. A wide range of functional, comparative and diagnostic cytogenetic techniques is utilized in these studies, which include conventional and molecular cytogenetics- FISH, comparative genomic hybridization (CGH), multicolor spectral karyotyping (SKY), and array CGH. The laboratory emphasizes the investigation of the relevance of newly discovered genetic markers to tumor classification and clinical stratification of patients. His laboratory is also focusing on the development of molecular cytogenetic techniques for the analysis of chromosomal aberrations in murine models of human cancers (Comparative Cancer Cytogenetics).

Learn more about the Cancer Cytogenetics Core Laboratory.

Education

Ph.D., Nagarjuna University, India
Post-doc, Department of Human Genetics, Memorial Sloan Kettering Cancer Center

Certifications

Clinical Laboratory Cytogenetics Director License – New York State Department of Health

Selected Memberships

Member, American Society for Human Genetics
Member, American Association for Advancement of Science
Member, American Association for Cancer Research (AACR)

Research Interests

Genetic basis of deregulation of cellular proliferation
Differentiation associated with malignant transformation

Research

The main goal of Dr. Pulivarthi Rao’s laboratory is the analysis of the genetic basis of deregulation of cellular proliferation and differentiation associated with malignant transformation.

The laboratory staff investigates several tumor types, most notably osteosarcoma and multiple myeloma. A wide range of functional, comparative and cytogenetic techniques is utilized in these studies, which include conventional and molecular cytogenetics- FISH, comparative genomic hybridization (CGH), multicolor spectral karyotyping (SKY), and array CGH. The laboratory emphasizes the identification of oncogenes from the amplified chromosomal regions and genomic insatbility in osteosarcoma. His laboratory is also focusing on the development of molecular cytogenetic techniques for the analysis of chromosomal aberrations in murine models of human cancers (Comparative Cancer Cytogenetics).

Dr. Pulivarthi Rao’s lab is part of the Cancer Genetics and Genomics Program, and the Sarcoma Research Labs.

Laboratory Members

Principal Investigator
Pulivarthi Rao, Ph.D.

Research Assistant
Yi-Jue Zhao

Methods

FISH by indirect labelling
Direct Labeling for FISH
Paraffin FISH
Protocol for Q Fish
Preparation of human lymphocyte metaphase chromosomes
CGH Protocol
Multicolor Spectral Karyotyping

Links

Mouse Nomenclature
Human Gene Nomenclature Guidelines
Molecular Cytogenetics Resources
SKY/m-FISH and CGH database
Cancer genetics
NCBI