Department of Pediatrics
Section of Hematology-Oncology
Baylor College of Medicine
Dr. Jason Yustein
1102 Bates Street, Suite 1025.07
Houston, TX 77030
Dr. Jason Yustein’s research interests include furthering the biological, molecular and genetic understanding of pediatric sarcomas, including osteosarcoma and Ewing’s sarcoma, through the formation of novel model systems that will lead to the discovery of new therapeutic targets and subsequent development of new treatment interventions. For example, Dr. Yustein is utilizing osteoblast-specific expression of an oncogenic p53 mutant to form a novel, applicable transgenic mouse model of metastatic osteosarcoma, a condition that has a particularly poor prognosis. Such models will allow for further understanding of critical genes and microRNAs involved in sarcoma development, progression and metastasis and utilized as preclinical models for therapeutic testing and efficacy.
Learn about the Research Laboratory of Jason Yustein, MD, PhD
M.D., Ph.D., Case Western Reserve University
Residency, Johns Hopkins University
Fellowship, Johns Hopkins University and the National Cancer Institute
American Board of Pediatrics
American Board of Pediatrics – Hematology/Oncology
Member, American Academy of Pediatrics (AAP)
Member, American Society for Pediatric Hematology/Oncology (ASPHO)
Cancer Stem Cells
Hypoxia-regulated genetic effects in tumors
1: Ghosal G, Yustein JT. GEWS-FLI1 Regulates Genotoxic Stress Response in Ewing Sarcoma, J Cancer Biol Res. 2015 May 6; 3(2): 1063.
2: Roos A, Satterfield L, Zhao S, Fuja D, Shuck R, Hicks JM, Donehower LA, Yustein JT. Loss of Runx2 sensitizes osteosarcoma to chemotherapy-induced apoptosis, accepted, British Journal of Cancer. (Corresponding author)
3: Rao P H, Kurenbekova L, Rainusso N, Trucco M, Allen-Rhoades W, Borra V P, Man T, Donehower LA , Yustein JT. Co-Amplification of Myc/Pvt1 and Homozygous Deletion of Nlrp1 Locus are the Frequent Genetics Changes in Mouse Osteosarcoma, accepted, Genes Chromosomes and Cancer. (Corresponding author)
4: Allen-Rhoades W, Kurenbekova L, Satterfield L, Parikh N, Fuja D, Shuck RL, Rainusso N, Trucco M, Barkauskas DA, Jo E, Ahern C, Hilsenbeck S, Donehower LA, Yustein JT. Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma. Cancer Med. 2015 Jul; 4(7):977-88.
5: Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, Yustein JT. NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. 2015 Jan 12.
6: Rainusso N, Wang LL, Yustein JT. The adolescent and young adult with cancer: state of the art — bone tumors. Curr Oncol Rep. 2013 Aug; 15(4):296-307.
7: Wu G, Yustein JT, McCall MN, Zilliox M, Irizarry RA, Zeller K, Dang CV, Ji H. ChIP-PED enhances the analysis of ChIP-seq and ChIP-chip data. Bioinformatics. 2013 May 1; 29(9):1182-9.
8: Ke S, Wang W, Qiu X, Zhang F, Yustein JT, Cameron AG, Zhang S, Yu D, Zou C, Gao X, Lin J, Yallampalli S, Li M. Multiple target-specific molecular agents for detection and image analysis of breast cancer characteristics in mice. Curr Mol Med. 2013 Mar; 13(3):446-58.
9: Awad O, Yustein JT, Shah P, Gul N, Katuri V, O’Neill A, Kong Y, Brown ML, Toretsky JA, Loeb DM. High ALDH activity identifies chemotherapy-resistant Ewing’s sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. PLoS One. 2010 Nov 11; 5(11):e13943.
10: Yustein JT, Rednam S, Bertuch AA, Goss JA, Brandt ML, Eldin K, Lu X, Hicks J. Abdominal undifferentiated small round cell tumor with unique translocation (X;19)(q13;q13.3). Pediatr Blood Cancer. 2010 Jul 1; 54(7):1041-4.