Research Co-Director, Neuroblastoma Program
Texas Children’s Cancer Center
Department of Pediatrics,
Section of Hematology-Oncology
Baylor College of Medicine
Dr. Jason Shohet
1102 Bates Street, Suite 1750.01
Houston, TX 77030
Dr. Jason Shohet’s research is focused on developing better molecular targeted therapies for neuroblastoma and other solid tumors. Mortality and morbidity from neuroblastoma is still a major challenge in pediatric oncology and novel improved therapies are urgently needed. Effective biologically specific therapies will derive from a deeper understanding of the molecular processes crucial for tumor transformation and progression. An ideal therapeutic target is essential for tumor development and growth, is amenable to genetic or pharmacologic destruction and can be specifically targeted in malignant cells.
Recent efforts from the laboratory include defining a novel set of MYCN regulated microRNAs that have tumor suppressive or oncogenic effects. In addition, the interaction of the MYCN oncogene with p53 and the role of MYCN and microRNA mediated repression of apoptosis has been a focus. Clinical translational efforts include testing novel MDM2 and STAT3 inhibitors as well as novel platforms (including nanoparticle based methods) to deliver drugs and inhibitory small RNA directly to cancer cells in vivo.
Most recently we are completing the characterization of a novel cancer stem cell population in neuroblastoma. Novel findings from the field of stem cell reprogramming and cancer stem cell biology are generating exciting new hypotheses regarding the role of multipotent cancer stem cell populations in tumorigenesis and cancer relapse. We are utilizing novel approaches to identify and characterize neuroblastoma specific cancer stem cells which have a great promise as a therapeutic approach for pediatric solid tumors.
Dr. Shohet is Research Co-Director of the Neuroblastoma Program.
B.A., Chemistry, Reed College
M.D. and Ph.D., Boston University School of Medicine
Internship, Residency and Fellowship, Baylor College of Medicine
Fellowship, University of Texas Southwestern Medical Center
American Board of Pediatrics
American Board of Pediatrics-Hematology/Oncology
Cancer Stem Cell biology
Cellular reprogramming / epigenetics
MicroRNA function as oncogenes and tumor suppressors
Novel tumor markers
Molecular targeted therapies for neuroblastoma and solid tumors
Transgenic and orthotopic models for neuroblastoma